TMA Mailsi spreads over an area of 1,639 square kilometres with a population of 704,878(as per DCR 1998). Mailsi is located at 35 km from Vehari. It can also be accessed from Lahore-Multan highway. It is located on the right bank of river Sutlej. It is at a distance of 90 KM from Multan, on its south-east, and connected to it by metalled road, off-taking at Tibba Sultan Pur on main Multan-Vehari Road. Mailsi-Vehari Section of Pakistan Railways passes through Mailsi.

Mailsi was raised to the status of Municipal Committee in the year 1952. After the implementation of Punjab Local Government Ordinance 2001, it attained the present status of TMA.